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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 4
2001 4
2002 8
2003 8
2004 6
2005 13
2006 13
2007 3
2008 9
2009 3
2010 9
2011 4
2012 5
2013 9
2014 5
2015 12
2016 9
2017 9
2018 8
2019 3
2021 2
2022 7
2023 6
2024 0

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145 results

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Page 1
GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions.
Brun S, Bestion E, Raymond E, Bassissi F, Jilkova ZM, Mezouar S, Rachid M, Novello M, Tracz J, Hamaï A, Lalmanach G, Vanderlynden L, Legouffe R, Stauber J, Schubert T, Plach MG, Courcambeck J, Drouot C, Jacquemot G, Serdjebi C, Roth G, Baudoin JP, Ansaldi C, Decaens T, Halfon P. Brun S, et al. Autophagy. 2022 Mar;18(3):678-694. doi: 10.1080/15548627.2021.1988357. Epub 2021 Nov 5. Autophagy. 2022. PMID: 34740311 Free PMC article.
Hepatocellular carcinoma is the most frequent primary liver cancer. Macroautophagy/autophagy inhibitors have been extensively studied in cancer but, to date, none has reached efficacy in clinical trials. In this study, we demonstrated that GNS561, a new autophagy inhibitor …
Hepatocellular carcinoma is the most frequent primary liver cancer. Macroautophagy/autophagy inhibitors have been extensively studied …
Multidimensional Analysis of PANoptosis-Related Molecule CASP8: Prognostic Significance, Immune Microenvironment Effect, and Therapeutic Implications in Hepatocellular Carcinoma.
Peng F, Zhu F, Cao B, Peng L. Peng F, et al. Genet Res (Camb). 2023 Dec 30;2023:2406193. doi: 10.1155/2023/2406193. eCollection 2023. Genet Res (Camb). 2023. PMID: 38186679 Free PMC article.
Mutation analysis indicated a higher frequency of TP53 mutations in patients with elevated CASP8 expression. In addition, CASP8 was found to regulate YEATS2 in HCC, highlighting a potential pathway in tumor progression. CONCLUSIONS: Our study underscores the multifa …
Mutation analysis indicated a higher frequency of TP53 mutations in patients with elevated CASP8 expression. In addition, CASP8 …
Upregulation of SATB1 promotes tumor growth and metastasis in liver cancer.
Tu W, Luo M, Wang Z, Yan W, Xia Y, Deng H, He J, Han P, Tian D. Tu W, et al. Liver Int. 2012 Aug;32(7):1064-78. doi: 10.1111/j.1478-3231.2012.02815.x. Epub 2012 May 14. Liver Int. 2012. PMID: 22583549
AIMS: This study aimed to confirm the effects of SATB1 on the growth and metastasis of liver cancer and its specific regulation mechanism. METHODS: SATB1 expression was evaluated in human hepatoma tissue, adjacent noncancerous tissue and seven kinds of liver cancer …
AIMS: This study aimed to confirm the effects of SATB1 on the growth and metastasis of liver cancer and its specific regulation mecha …
A Pyroptosis-Related Gene Signature to Predict Patients' Prognosis and Immune Landscape in Liver Hepatocellular Carcinoma.
Wang J, Huang Z, Lu H, Zhang R, Feng Q, He A. Wang J, et al. Comput Math Methods Med. 2022 Feb 16;2022:1258480. doi: 10.1155/2022/1258480. eCollection 2022. Comput Math Methods Med. 2022. PMID: 35242200 Free PMC article.
BACKGROUND: Liver hepatocellular carcinoma (LIHC) is a malignance with high incidence and recurrence. ...A prognostic signature constructed by the above 14 prognostic PRGs had moderate to high accuracy to predict LIHC patients' prognosis. And risk score was correlated with …
BACKGROUND: Liver hepatocellular carcinoma (LIHC) is a malignance with high incidence and recurrence. ...A prognostic signature const …
2-DG-Regulated RIP and c-FLIP Effect on Liver Cancer Cell Apoptosis Induced by TRAIL.
Zhang Y, Huang F, Wang J, Luo H, Wang Z. Zhang Y, et al. Med Sci Monit. 2015 Nov 10;21:3442-8. doi: 10.12659/msm.895034. Med Sci Monit. 2015. PMID: 26552967 Free PMC article.
This paper aimed to investigate the effect of 2-DG on RIP and c-FLIP expression in HepG2 and Hep3B cells, further illustrating the effect and mechanism of 2-DG regulating RIP and c-FLIP expression on liver cancer cell apoptosis induced by TRAIL. MATERIAL AND METHODS: RIP a …
This paper aimed to investigate the effect of 2-DG on RIP and c-FLIP expression in HepG2 and Hep3B cells, further illustrating the effect an …
Diarylheptanoids/sorafenib as a potential anticancer combination against hepatocellular carcinoma: the p53/MMP9 axis of action.
Elmetwalli A, Diab T, Albalawi AN, El-Naggar SA, El-Far AH, Ghedan AR, Alamri ES, Salama AF. Elmetwalli A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2023 Oct;396(10):2501-2517. doi: 10.1007/s00210-023-02470-0. Epub 2023 May 5. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 37145126 Free PMC article.
The outcomes demonstrated that DAH and SOR-treated HCC-bearing mice displayed a reduction in the tumour burden and liver damage as demonstrated by (1) parameters of repaired liver function; (2) low levels of hepatic MDA; (3) elevated levels of hepatic T-SOD; (4) p53 …
The outcomes demonstrated that DAH and SOR-treated HCC-bearing mice displayed a reduction in the tumour burden and liver damage as de …
Protective effect of RIP and c-FLIP in preventing liver cancer cell apoptosis induced by TRAIL.
Sun J, Luo H, Nie W, Xu X, Miao X, Huang F, Wu H, Jin X. Sun J, et al. Int J Clin Exp Pathol. 2015 Jun 1;8(6):6519-25. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 26261530 Free PMC article.
The study aimed to explore the role of RIP and c-FLIP genes in TRAIL induced liver cancer cell HepG2 and Hep3B apoptosis and related mechanism. ...
The study aimed to explore the role of RIP and c-FLIP genes in TRAIL induced liver cancer cell HepG2 and Hep3B apoptosis and related …
Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver.
Li H, Fan X, Stoicov C, Liu JH, Zubair S, Tsai E, Ste Marie R, Wang TC, Lyle S, Kurt-Jones E, Houghton J. Li H, et al. Gastroenterology. 2009 Sep;137(3):934-44, 944.e1-4. doi: 10.1053/j.gastro.2009.06.004. Epub 2009 Jun 12. Gastroenterology. 2009. PMID: 19524576 Free PMC article.
Coexpression of Fas L enables colon cancer cells to metastasize to the liver from local tumors as well as from intravenous injection of cells. ...CONCLUSIONS: Alterations in the Fas Ag pathway which inhibit apoptosis and increase Fas-mediated proliferation directly increas …
Coexpression of Fas L enables colon cancer cells to metastasize to the liver from local tumors as well as from intravenous injection …
Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma.
Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A. Nishida N, et al. Hepatology. 2008 Mar;47(3):908-18. doi: 10.1002/hep.22110. Hepatology. 2008. PMID: 18161048 Free PMC article.
The current study is a comprehensive methylation analysis of human liver tissue specimens. A total of 176 liver tissues, including 77 pairs of HCCs and matching noncancerous liver and 22 normal livers, were analyzed for methylation. ...Based on methylation pr …
The current study is a comprehensive methylation analysis of human liver tissue specimens. A total of 176 liver tissues, inclu …
High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer.
Jiang R, Xia Y, Li J, Deng L, Zhao L, Shi J, Wang X, Sun B. Jiang R, et al. Int J Cancer. 2010 Mar 1;126(5):1263-74. doi: 10.1002/ijc.24854. Int J Cancer. 2010. PMID: 19728335 Free article.
IKK-NF-kappaB signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy. Therefore, in this study, we analyzed the expression of mRNAs encoding components and targets of NF-kappaB signaling including IKKalpha, IKKb …
IKK-NF-kappaB signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy. T …
145 results